Thursday, December 28, 2017

lung disease as a hereditary one

Hereditary lung diseases can affect the airways (asthmaCOPDcystic fibrosisand primary ciliary dyskinesia), parenchyma (pulmonary fibrosis, Birt–Hogg–Dubé syndrome and, tuberous sclerosis) and vasculature (hereditaryhaemorrhagic telangiectasia) of the lung.
Hereditary lung diseases can affect the airways (asthma, COPD, cystic fibrosis and primary ciliary dyskinesia), parenchyma (pulmonary fibrosis, Birt–Hogg–Dubé syndrome and, tuberous sclerosis) and vasculature (hereditary haemorrhagic telangiectasia) of the lung. Such conditions include simple monogenic disorders such as Kartagener syndrome and α1‐antitrypsin, wherein mutations of critical genes are sufficient to induce well‐defined disease phenotypes. However, many are complex genetic traits in which inheritance subtly affects pathogenesis, for example asthma and idiopathic pulmonary fibrosis. A greater understanding of the genetic basis of pulmonary conditions has provided new insights into their underlying pathophysiology and helped in some cases to shed light on more common sporadic forms. Importantly, the identification of  may be a hereditary one.genes has also enabled prenatal diagnosis and genetic counselling to be introduced for many diseases.eas
My lung disease may be a hereditary one.

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